CN12 Impact of diet on immune checkpoint blockade: Nurse-directed dietary intervention

Gut microbiota modulates the response to immune checkpoint blockade (ICB) in various cancers, and diet represents most natural non-evasive method shift its composition. A recent study suggests that a high dietary fiber intake may improve progression-free survival (PFS) of melanoma patients treated with ICB. However, impact on advanced non-small cell lung cancer (NSCLC) has not been yet investigated. The objective this was assess effect diet, including intake, NSCLC amenable Our research nurse assessed habits 102 ICB using food frequency questionnaire (FFQ) probiotics supplementation (approved by ethics committee). Upon consent each participant, answers 47 questions included FFQ were recorded, analysed calculation tool estimate 30 different nutrients correlated PFS. total (49% men) completed survey median age 67 years follow-up 18.6 months. In contrast melanoma, did correlate an improved PFS (median PFS: low fiber=16.0 months versus fiber=9.8 months, p=0.42) NSCLC. Of note, group 11g/day compared 20g/day study. Conversely, saturated fatty acids (SFA) favorable outcome SFA=9.1 SFA=17.4 p=0.03). sources SFA mostly from dairy products. our study, had very could explain absence benefit. longer With emergence gut immuno-oncology arena, providing evidence-based recommendations educational tools for nurses important strategy potentially increase efficacy.